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Nordmann

The hospital Bicêtre is a 1,000 beds University hospital unit located in the immediated Southern suburb of Paris(K-Bicêtre). It is part of the South-Paris medical school and University. This medical center has a department of Microbiology (Bacteriology, Virology, Hygiena, Parisitology and a research unit INSERM UMR914 headed by Prof P. Nordmann.

The unit of research and development INSERM UMR is supported by senior INSERM scientist Dr L. Poirel and Associated Professor Dr. T. Naas. It is made of around 15 persons including currently two post docs and two PhD students.

Members of the team participate to the medical student teaching at the South Paris Medical School and University and to many master degrees in several Universities in France and abroad.

The research is focused on the genetics and biochemistry of emerging antibiotic resistance traits in bacteria. Among the most preeminent resistance traits that are spreading worldwide and that are clinically relevant have been identified in this Unit. They are for example the extended-spectrum ß-lactamase CTX-M-15, the carbapenemases VIM-2 and OXA-48 that are spread worldwide in Enterobacteriaceae and the origin of multidrug resistance patterns. A worldwide-based network of sentinel labs has been established beiing the basis of fruitful collaboration. The natural reservoirs (bacterial species, environment) which are the source of many clinically-relevant antibiotic resistance traits have been identified the molecular mechanisms (transposition mostly) that are at the source of their transfers has reproduced in vitro and in vivo. Many novel genetic elements have been identified in Gram negatives that are vectors of those resistance traits (example transposons and the carbapenemase genes of the KPC type. Regulations of expression and relationship between regulation mechanisms and level of resistance have been studying in details for clinically-significant pathogens (Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii). Among the most recent achievement the first genome of an E. coli producing the carbapenemase NDM-1 has been done. Several molecular-, biochemical- and microbiology-based techniques have been developped for identification of among the most important resistance traits such as the carbapenemases of NDM, OXA-48 and KPC types. The goals of teh research are not only to study basic mechanisms behind the emergence of novel resistance mechanisms but also to identify it at the worldwide scale and to design useful diagnostic tools for making real the knowledge transfer from the bench to the bedside.

Collaboration and partnerships are developped on a daily basis with the Industry Since 2003, the research Unit have published more than 320 papers in peer-reviewed journals. The group has obtained recently four European/US patents.

7thframeworklogo The TEMPOtest-QC project has received funding from the European Community's Seventh Framework Programme [FP7/2007-2013] under grant agreement no 241742 EUFlag
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